Abstract：Objective To investigate the efficacy and safety of Xueshuantong Injection combined with Edaravone in the treatment of patients with acute cerebral infarction.Methods From January 2019 to December 2020,a total of 80 patients with acute cerebral infarction admitted to the Department of Integrated Traditional Chinese and Western Medicine of Xinyi Railway Hospital were selected as the research subjects.They were divided into the study group (40 cases)and the control group(40 cases)according to random number table method.Patients in the control group was treated with Edaravone,and in the study group,Xueshuantong Injection was added.The differences in the overall response rate of treatment,serum inflammatory indexes,cerebral hemodynamic indexes and the incidence of adverse drug reactions were compared between the two groups.Results The total effective rate of the study group was higher than that in the control group,and the difference was statistically significant (P＜0.05).There were no significant differences in the serum levels of tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),interleukin-23 (IL-23) and high-sensitivity C-reactive protein (hs-CRP)between the two groups before treatment (P＞0.05).After treatment,the above indexes of the two groups were lower than those before treatment,and the study group was lower than the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in the mean blood flow(Qm),mean blood flow velocity(Vm),total peripheral resistance(TPR),or dynamic resistance(DR)levels between the two groups before treatment(P＞0.05).After treatment,the Qm and Vm in the two groups were higher than those before treatment,while TPR and DR in the two groups were lower than those before treatment.And the Qm and Vm in the study group were higher than those in the control group,while TPR and DR in the study group were lower than those in the control group,with statistically significant differences (P＜0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups (P ＞0.05).Conclusion Xueshuantong Injection combined with Edaravone can be effectively used in the treatment of patients with acute cerebral infarction in safe,which can markedly alleviate inflammation and improve cerebral hemodynamic parameters,which is worthy of clinical promotion.
石春明. 血栓通注射液联合依达拉奉治疗急性脑梗死患者的临床效果[J]. 中国当代医药, 2022, 29(31): 105-108.
SHI Chunming. Clinical effect of Xueshuantong Injection combined with Edaravone in the treatment of patients with acute cerebral infarction. 中国当代医药, 2022, 29(31): 105-108.
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