Clinical effect of Wuling Capsules on sleep disorders induced by hormone pulse therapy for nephrotic syndrome
WANG Jiang ZHU Juqi SHI Chunzhen XIONG Qingdi YI Qinxia
Department of Nephrology,Jiujiang Hospital of Traditional Chinese Medicine,Jiangxi Kidney Research Institute of Chinese Medicine,Jiangxi Province,Jiujiang 332000,China
Abstract：Objective To explore the treatment effect of Wuling Capsules on sleep disorders induced by hormone pulse therapy for nephrotic syndrome.Methods A total of 100 patients with sleep disorders caused by hormone shock therapy for primary nephrotic syndrome in Jiujiang Hospital of Traditional Chinese Medicine from June 2019 to June 2020 were selected as the study subjects,and they were divided into the Wuling Capsules group(50 cases)and the Estazolam group(50 cases)according to the odd and even bed numbers.The Wuling Capsules group was treated with Wuling Capsules,and the Estazolam group was given Estazolam for treatment.The efficacy and Pittsburgh sleep quality index(PSQI),treatment emergent symptom scale(TESS)and the incidence rates of adverse reactions after treatment were compared between the two groups.Results The effective rate in the Wuling Capsules group at 6 weeks of treatment was higher than that in the Estazolam group,the difference was statistically significant(P＜0.05).The PSQI scores of the two groups showed decreasing trends at 6 weeks of treatment(P＜0.05),and the PSQI scores at 1,3 and 6 weeks of treatment in the Wuling Capsules group were lower than those in the Estazolam group,the differences were statistically significant(P＜0.05).The PSQI scores of the two groups showed significant upward trends after drug withdrawal(P＜0.05),and the PSQI scores at 1,3 and 6 weeks after drug withdrawal in the Wuling Capsules group were lower than those in the Estazolam group,the differences were statistically significant(P＜0.05).The TESS score in the Wuling Capsules group was lower than that in the Estazolam group,the difference was statistically significant(P＜0.05).The incidence rate of adverse reactions in the Wuling Capsules group was lower than that in the Estazolam group,the difference was statistically significant(P＜0.05).Conclusion Compared with Estazolam,the application of Wuling Capsules for patients with sleep disorders induced by hormone pulse therapy for nephrotic syndrome can better enhance the efficacy,improve the sleep quality and reduce the occurrence of adverse reactions.
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