Abstract：Objective To investigate the effect of Morphine Sustained Release Tablets and Oxycodone Sustained Release Tablets in moderate and severe cancer pain.Methods A total of 100 patients with moderate and severe cancer pain admitted to Zhongshan Hospital Affiliated to Dalian University from April 2019 to February 2021 were selected as research objects,they were divided into control group and observation group according to random number table method,with 50 cases in each group.The control group was treated with Morphine Sustained Release Tablets and the observation group was treated with Oxycodone Sustained Release Tablets.The analgesic efficiency,effective time of pain control and adverse reactions of the two groups were compared.Results There was no significant difference in the scores of numerical rating scale(NRS)between the two groups before treatment(P＞0.05).After treatment,the NRS score of the observation group was lower than that of the control group,the difference was statistically significant(P＜0.05).The effective time of the observation group was shorter than that of the control group,the difference was statistically significant(P＜0.05).The incidence of adverse reactions in the observation group(8%)was lower than that of the control group(32%),the difference was statistically significant(P＜0.05).Conclusion In the treatment of moderate and severe cancer pain,the effect of Morphine Sustained Release Tablets and Oxycodone Sustained Release Tablets are basically the same,but Oxycodone Sustained Release Tablets have faster effect and less adverse reactions.Clinical administration can be selected according to the actual situation.
刘曼;吴珊;赵森;徐保利. 吗啡缓释片与羟考酮缓释片在中重度癌性疼痛中的应用效果[J]. 中国当代医药, 2022, 29(10): 132-134.
LIU Man ;WU Shan ;ZHAO Sen; XU Baoli. Effect of Morphine Sustained Release Tablets and Oxycodone Sustained Release Tablets on moderate and severe cancer pain. 中国当代医药, 2022, 29(10): 132-134.
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