Abstract：Objective To explore the clinical effect of laparoscopic radical prostatectomy combined with neoadjuvant hormonal therapy(NHT)for T3N0M0 prostate cancer.Methods The clinical data of 72 patients with T3N0M0 stage prostate adenocarcinoma admitted to Urology of Fujian Provincial Hospital and Fujian Provincial Jinshan Hospital from January 2010 to July 2019 were retrospectively analyzed.They were divided into the experimental group(38 cases)and the control group(34 cases)according to whether NHT was used.The experimental group were treated by laparoscopic radical prostatectomy combined with NHT.The control group were treated by laparoscopic radical prostatectomy.The operation time,intraoperative blood loss,serum prostate specific antige(PSA)level,postoperative incision margin positive,rectal injury,urinary incontinence,anastomotic leakage and erectile dysfunction were compared between the two groups.Results There was no significant difference in the operation time between the two groups(P>0.05).There was no significant difference in the amount of bleeding between the two groups(P>0.05).The number of positive cases in the experimental group was less than that in the control group,the difference was statistically significant(P<0.05).The serum PSA level in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05).There were no significant differences in the number of rectal injury,urinary incontinence,urinary fistula and erectile dysfunction between the two groups(P>0.05).Conclusion Laparoscopic radical prostatectomy combined with NHT in the treatment of T3N0M0 stage prostate cancer is safe and effective,which could significantly reduce the positive rate of surgical margin,and have no effect on the operation difficulty and postoperative complications,which is worthy of clinical promotion.
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