Study on the correlation between homocysteine level and bone metabolism markers in patients with fist-episode schizophrenia
WU Yong1 WAN Jing2 PING Jun-jiao3 HUANG Cai-ying2 DU Qi-feng1 DU Bao-guo2▲
1. Department of Medical Administration, Zhongshan Third People′ s Hospital
2. Department of Early Intervention, Zhongshan Third People′s Hospital
3. Department of Science and Education (Institute of Mental Health), Zhongshan Third People′s Hospital
Abstract： Objective To investigate the correlation between homocysteine (HCY) level and bone metabolic markers in patients with first-episode schizophrenia.Methods A total of 69 patients with first-episode schizophrenia who were admitted to Zhongshan Third People′s Hospital from May 2016 to April 2020 were selected as the research objects according to the International Classification of Diseases 10th edition Mental and Behavioral Disorders. Patients were divided into high HCY group (HCY>15.4 μmol/L, with 31 cases) and normal HCY group (HCY≤15.4 μmol/L, with 38 cases) according to the HCY level of patients.General data,HCY,bone metabolism markers(osteocalcin[OCN], β-collagen breakdown product [β-CTX], 25-hydroxy vitamin D [VitD-T], procollagen type ⅠN propeptide [PⅠNP] and parathyroid hormone [PTH]) and cerebrovascular-related indexes (triacylglycerol [TG], total cholesterol [TC], high-sensitivity C-reactive protein [hs-CRP], high-density lipoprotein [HDL], low density lipoprotein [LDL], creatine kinase [CK], creatine kinase isoenzyme [CK-MB]) in the two groups were collected, and their differences and correlation were analyzed. Results The levels of CK, CK-MB and PⅠNP in the high HCY group were higher than those in the normal HCY group, and the differences were statistically significant (P<0.05). There were no significant differences in the levels of hs-CRP, TG, TC,HDL, OCN, β-CTX, VitD-T, PTH and LDL between the two groups (P>0.05). Correlation analysis showed that HCY level was positively correlated with CK, CK-MB and HDL levels in schizophrenia patients (P<0.05). HCY was positively correlated with PⅠNP (P<0.05). Conclusion HCY level has a certain correlation with bone metabolism markers in patients with first-episode schizophrenia, and also has a certain correlation with cerebrovascular-related indexes.
吴勇；万静；平军娇；黄彩英；杜启峰；杜宝国. 首发精神分裂症患者同型半胱氨酸水平和骨代谢标志物相关性研究[J]. 中国当代医药, 2021, 28(16): 82-85.
WU Yong；WAN Jing；PING Jun-jiao；HUANG Cai-ying；DU Qi-feng；DU Bao-guo. Study on the correlation between homocysteine level and bone metabolism markers in patients with fist-episode schizophrenia. 中国当代医药, 2021, 28(16): 82-85.
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