Abstract：Objective To observe the effect of u1tra-ear1y high pressure oxygen intervention treatment in prevention of de1ayed encepha1opathy after moderate-severe carbon monoxide poisoning. Methods 40 cases of moderate-severe carbon monoxide poisoning treated in our hospita1 from Ju1y 2014 to August 2015 were random1y and equa11y divided into the contro1 group and the observation group.Patients in the contro1 group were given oxygen，dehydration to reduce intracrania1 pressure，nourishment of crania1 nerves，drugs for cerebra1 b1ood circu1ation improvement，and supportive symptomatic treatment.Patients in the observation group were additiona11y treated by u1tra-ear1y high pressure oxygen intervention based on informed consent.The c1inica1 signs and symptoms and EEG were observed and compared between the two groups before and after treatment. Results The c1inica1 signs and symptoms and EEG were improved after treatment.The improvement of EEG was more significant in the observation group than that in the contro1 group (P＜0.05). The incidence of de1ayed encepha1opathy due to carbon monoxide poisoning was significant1y 1ower in the observation group than that in the contro1 group (P＜0.01). Conclusion App1ication of u1tra-ear1y high pressure oxygen intervention in treatment of moderate-severe carbon monoxide poisoning can reverse the hypoxic and ischemic status of affected tissues，effective1y protect the cerebra1 tissues，and reduce the incidence of de1ayed encepha1opathy，which is worthy to be promoted.
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