Clinical intervention and Pregnancy outcome study of subclinical hy-Pothyroidism combining with infertility or sPontaneous miscarriage
LIU Zhao-xia1 XIE Xiao-ying1 WANG Qin1 LV Wei-ming2 MA Hua-mou3
1.Department of Gyneco1ogy and Obstetrics,the First Affi1iated Hospita1 of Gannan Medica1 University in Jiangxi Province,Ganzhou 341000,China;
2.Department of Endocrino1ogy,the First Affi1iated Hospita1 of Gannan Medica1 University in Jiangxi Province,Ganzhou 341000,China;
3.C1inica1 Experiment Center,the First Affi1iated Hospita1 of Gannan Medica1 University in Jiangxi Province,Ganzhou 341000,China
Abstract：Objective To exp1ore the c1inica1 effect of c1inica1 intervention for subc1inica1 hypothyroidism combined with inferti1ity patients with natura1 abortion and pregnancy outcome. Methods From January 2012 to January 2015,60 subc1inica1 hypothyroidism patients with inferti1ity or spontaneous miscarriage visited our outpatient c1inic of reproductive medicine department were se1ected as research objects.Based on patient's wi11 and requirements,they were even1y divided into research group and contro1 group,with 30 cases in each group.In the research group,ora1 administration of 1evothyroxine was provided,whi1e in the contro1 group,no intervention was app1ied.The pregnancy rate and miscarriage rate in the both groups were observed. Results The pregnancy rate and miscarriage rate in the research group was 26.67% and 12.5% respective1y,whi1e they were 10% and 66.67% in the contro1 group.There was statistica1 difference in comparison of pregnancy rate (P＜0.05) and miscarriage rate (P＜0.01) in the two groups.There was statistica1 difference of TSH after treatment in research group（P＜0.05）. Conclusion For patients with subc1inica1 hypothyroidism and inferti1ity or spontaneous miscarriage,app1ication of 1evothyroxine as an intervention can great1y improve thyroid function, pregnancy rate,and decrease miscarriage rate,and fina11y improve pregnancy outcomes.
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