Analysis of the related factors of type 2 diabetes combined with non-alcoholic fatty liver in Gannan area
Zhang Lei1 KE Rui-qiong2▲ XIE Jun1 HUANG Cai-bin1
1.Department of Gastroentero1ogy，the First Affi1iated Hospita1 of Gannan Medica1 Co11ege，Gannan341000，China；
2.Department of Endocrino1ogy，the First Affi1iated Hospita1 of Gannan Medica1 Co11ege，Gannan341000，China
摘要目的探讨赣南地区2型糖尿（T2DM）合并非酒精性脂肪肝（NAFLD）的相关因素，为赣南地区的T2DM合并NAFLD防治提供科学依据。方法回顾性分析2013年10月～2015年10月本院收治的392例T2DM住院患者的临床资料，根据腹部彩超定性测定结果分为A组（合并NAFLD）和B组（未合并NAFLD）。比较两组的身高、体重、年龄、血压、腰围（WC）、臀围及丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、谷氨酰转肽酶（GGT）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、空腹血糖（FPG）、餐后2 h血糖（2 h PG）、尿素氮（BUN）、肌酐（SCr）、尿酸（UA）、糖化血红蛋白（HbA1c），空腹胰岛素（FINS）及空腹C肽（FCP），计算腰臀比（WHR）、体质指数（BMI）及胰岛素抵抗（IR）。采用Logistic回归分析，探讨T2DM合并NAFLD的相关危险因素。结果A组的舒张压（DBP）、BMI、WC、TC、TG、LDL-C、ALT、UA、AST及HOMA-IR水平显著高于B组，FINS、FCP水平显著低于B组，差异有统计学意义（P＜0.05）。两组的收缩压（SBP）、BUN、SCr及HbA1c水平比较，差异无统计学意义（P＞0.05）。多因素Logistic回归分析结果显示，BMI、WC、TG、HOMA-IR是T2DM合并NAFLD的主要危险因素（P＜0.05）。结论合并NAFLD的T2DM患者易发生血脂异常及肝功能损害。肥胖与胰岛素抵抗在T2DM患者NAFLD的发生、发展中起到一定作用，应重视体重控制并改善胰岛素抵抗，防治T2DM合并NAFLD。
Abstract：ObjectiveToexp1orethere1atedfactorsoftype2diabetes（T2DM）combinedwithnon-a1coho1icfatty1iver（NAFLD）in Gannan area，and to provide scientific basis for prevention and cure of T2DM combined with NAFLD in Gannan.Methods C1inica1 data of 392 T2DM patients from October 2013 to October 2015 in our hospita1 were retrospective ana1yzed，a11 patients were divided into group A（NAFLD）and group B（non-NAFLD）according to qua1itative determination of abdomina1 co1or Dopp1er u1trasound resu1ts.The indexes of height，weight，age，b1ood pressure，waist circumference（WC）and hip1ine，ALT，AST，GGT，TC，TG，HDL-c，LDL-c，FPG，2 h PG，BUN，SCr，UA，HbA1c，FINS，FCP，WHR，BMI and IR in the two groups was compared respective1y.Logistic regression ana1ysis was used to exp1ore the re1ated risk factors of T2DM combined with NAFLD.Results The 1eve1 of DBP，BMI，WC，TC，TG，LDL-C，ALT，UA，AST，HOMA-IR in group A was higher than that in group B，the 1eve1 of FINS and FCP in group A was 1ower than that in group B，with significant difference（P＜0.05）.There was no significant difference in the 1eve1 of SBP，BUN，SCr and HbA1c between the two groups（P＞0.05）. The mu1tip1e factors Logistic regression ana1ysis showed that BMI，WC，TG and HOMA-IR were main1y risk factors of T2DM combined with NAFLD（P＜0.05）.Conclusion T2DM patients with NAFLD are prone to dys1ipidemia and 1iver function damage.Obesity and insu1in resistance p1ay a certain ro1e in the occurrence and deve1opment of NAFLD in patients with T2DM，and weight contro1 and improvement of insu1in resistance shou1d be paid attention to the prevention and treatment of T2DM combined with NAFLD.
张蕾;柯瑞琼;谢军;黄才斌. 赣南地区2型糖尿病合并非酒精性脂肪肝相关因素分析[J]. 中国当代医药, 2016, 23(18): 32-34.
Zhang Lei;KE Rui-qiong;XIE Jun;HUANG Cai-bin. Analysis of the related factors of type 2 diabetes combined with non-alcoholic fatty liver in Gannan area. 中国当代医药, 2016, 23(18): 32-34.
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