Expression and correlation of MTA1 and Ki-67 in non small cell lung cancer
LI Hao1 YAN Cong-ying2 HOU Dian-chen3▲
1.Clinical Medical School of Inner Mongolia University for Nationalities,Tongliao 028000,China;
2.Department of Cardiology,the First Hospital of Hebei Medical University,Shijiazhuang 050000,China;
3.Department of Thoracic Surgery, the Second Clinical Medical School of Inner Mongolia University for Nationalities(Inner Mongolia Forestry General Hospital),Yakeshi 022150,China
Abstract：ObjectiveTo investigate the expressions of metastasis associated protein 1(MTA1)and proliferating cell nuclear antigen(Ki-67)in non-small cell lung cancer(NSCLC)tissues and their correlation.Methods46 cases of NSCLC tissues and 20 cases of normal tissues in Inner Mongolia Forestry General Hospital from January 2011 to January 2017 were selected as the research objects,immunohistochemistry of SP was used to detect the expressions of MTA1 and Ki-67 in NSCLC tissues and adjacent paracancerous tissues.The correlation between their expression and pathologic parameters were analyzed by statistics.ResultsThe positive expressions rate of MTA1 and Ki-67 in NSCLC tissues were 65.22%and 54.35%,significantly higher than the positive expressions rate of 15%and 20%in normal tissues(P<0.05); there was no significant relationship between the expressions of MTA1 and Ki-67 in NSCLC tissues(r=0.064,P>0.05); the positive expression rate of MTA1 in the group of lymph node metastasis of NSCLC was higher than that without lymph node metastasis(P<0.05);the positive expression rate of Ki-67 in low differentiation group of NSCLC was higher than that in high differentiation group(P<0.05).ConclusionThe abnormal expressions of MTA1 and Ki-67 may play an important role in the invasion and metastasis of NSCLC.
李浩;闫聪颖;侯殿臣. MTA1、Ki-67在非小细胞肺癌中的表达及相关性分析[J]. 中国当代医药, 2017, 24(11): 84-86.
LI Hao;YAN Cong-ying;HOU Dian-chen. Expression and correlation of MTA1 and Ki-67 in non small cell lung cancer. 中国当代医药, 2017, 24(11): 84-86.
Kumar R，Wang RA.Structure，expression and functions of MTA genes[J].Gene，2016，582（2）：112-121.
[2]
Yang H，Xu L，Qian H，et al.Correlation between insulinlike growth factor binding protein 3 and metastasis associ ated gene 1 protein in esophageal squamous cell carcinoma[J]. Mol Med Rep，2016，13（5）：4143-4150.
[3]
Choy B，LaLonde A，Que J，et al.MCM4 and MCM7，potential novel proliferation markers，significantly correlated with Ki-67，Bmi1，and cyclin E expression in esophageal adenocarcinoma，squamous cell carcinoma，and precancerous lesions[J].Hum Pathol，2016，57：126-135.
[4]
Mungle T，Tewary S，Arun I，et al.Automated characterization and counting of Ki-67 protein for breast cancer prognosis：a quantitative immunohistochemistry approach[J]. ComputMethodsPrograms Biomed，2017，139：149-161.
Azadeh Andisheh-Tadbir，Ali Dehghani-Nazhvani，Mohammad Javad Ashraf，et al.MTA1 Expression in Benign and Malignant Salivary gland Tumors[J].Iran J Otorhinolaryngol，2016，28（84）：51-59.
[9]
Fan C，Lin Y，Mao Y，et al.MicroRNA-543 suppresses colorectalcancergrowthandmetastasisbytargetingKRAS，MTA1 and HMGA2[J].Oncotarget，2016，7（16）：21825-21839.
Sinn HP，Schneeweiss A，Keller M，et al.Comparison of immunohistochemistry with PCR for assessment of ER，PR，and Ki-67 and prediction of pathological complete response in breast cancer[J].BMC Cancer，2017，17（1）：124.
[15]
Chierico L，Rizzello L，Guan L，et al.The role of the two splice variants and extranuclear pathway on Ki-67 regulation in non-cancer and cancer cells[J].PLoS One，2017，12（2）：e0171815.
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