左炔诺孕酮宫内节育系统联合地屈孕酮在子宫腺肌病中的应用效果

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摘要目的探讨左炔诺孕酮宫内节育系统联合地屈孕酮在子宫腺肌病（AM）中的应用效果。方法选取2019年1月至2021年12月宜春市人民医院妇产科的70例AM患者为研究对象，采用摸球法将其分为研究组与对照组，每组各35例。对照组患者给予左炔诺孕酮宫内节育系统治疗，研究组患者给予左炔诺孕酮宫内节育系统联合地屈孕酮治疗。比较两组患者治疗前后的月经情况、子宫情况及性激素水平、点滴出血及意外脱落率、治疗总有效率。结果治疗前，两组的月经量、疼痛程度、子宫内膜厚度、子宫体积等比较，差异无统计学意义（P＞0.05）。研究组治疗后的月经量少于对照组，疼痛程度低于对照组，子宫内膜厚度、子宫体积小于对照组，差异有统计学意义（P＜0.05）。治疗前，两组的黄体生成素（LH）、血清卵泡刺激素（FSH）、雌二醇（E2）水平比较，差异无统计学意义（P＞0.05）；研究组治疗后的E2水平高于对照组，差异有统计学意义（P＜0.05）。研究组的点滴出血率、意外脱落率低于对照组，差异有统计学意义（P＜0.05）。研究组的治疗总有效率高于对照组，差异有统计学意义（P＜0.05）。结论左炔诺孕酮宫内节育系统联合地屈孕酮治疗AM的效果显著，能有效改善患者的临床症状，防止不良事件的发生，提高患者的生活质量。

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关键词 ：子宫腺肌病, 左炔诺孕酮宫内节育系统, 地屈孕酮, 治疗效果, 性激素水平, 月经情况

Abstract：Objective To investigate the application effect of Levonorgestrel Intrauterine Contraceptive System with Didroxyprogesterone in adenomyosis (AM). Methods A total of 70 cases of AM patients from the Department of Obstetrics and Gynecology of Yichun People′s Hospital from January 2019 to December 2021 were selected as the study subjects, and they were divided into the study group and the control group, with 35 cases in each group. The patients in the control group were treated with Levonorgestrel Intrauterine Contraceptive System, and the patients in the study group were treated with Levonorgestrel Intrauterine Contraceptive System combined with Didroxyprogesterone. The menstrual situation, uterine situation, sex hormone level, the rate of drip bleeding and accidental exfoliation and the total effective rate were compared between the two groups before and after treatment. Results Before treatment, there were no significant differences in the menstrual volume, pain degree, endometrial thickness and uterine volume between the two groups (P＞0.05). The menstrual volume of the study group after treatment was less than that of the control group, the degree of pain of the study group after treatment was less than that of the control group, and the endometrial thickness and uterine volume of the study group after treatment were less than those of the control group, the differences were statistically significant (P＜0.05). Before treatment, there were no significant differences in the levels of luteinizing hormone (LH), serum follicle stimulating hormone (FSH) and estradiol (E2) between the two groups (P＞0.05). The level of E2 of the study group after treatment was higher than that of the control group, the difference was statistically significant (P＜0.05). The drip bleeding rate and the accidental shedding rate in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05). The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Levonorgestrel Intrauterine Contraceptive System combined with Didroxyprogesterone was effective in treating AM, which can effectively improve the clinical symptoms, prevent adverse events and improve the quality of life.

Key words： Adenomyosis Levonorgestrel Intrauterine Birth Control System Dydrogesterone Therapeutic effect Sex hormone levels Menstrual situation

基金资助:江西省卫生健康委科技计划项目（202212647）

引用本文:

潘虹1 李媛2 林红1 黄小平1. 左炔诺孕酮宫内节育系统联合地屈孕酮在子宫腺肌病中的应用效果[J]. 中国当代医药, 2022, 29(20): 102-104转108.
PAN Hong； LI Yuan； LIN Hong； HUANG Xiaoping. Application effect of Levonorgestrel Intrauterine Contraceptive System combined with Didroxyprogesterone in adenomyosis. 中国当代医药, 2022, 29(20): 102-104转108.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I20/102

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