Abstract：Objective To investigate the effect of Tovastaptan assisted with Berprost Sodium in patients with heart failure caused by pulmonary hypertension.Methods A total of 60 patients with heart failure caused by pulmonary hypertension admitted to Jiujiang First People′s Hospital from June 2020 to January 2021 were selected as the research subjects,and they were divided into control group (30 cases) and research group (30 cases) according to random throwing method.The control group was treated with basic treatment combined with Beprost Sodium,and the study group was treated with Tovaptan on the basis of the control group.Blood sodium,blood potassium,endocrine factors,serum creatinine and adverse reactions were compared between the two groups.Results The disappearance time of edema,relief time of shortness of breath and improvement time of fatigue in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment,there was no significant difference in serum potassium,creatinine and sodium between the two groups (P＞0.05).After treatment,the serum potassium and sodium levels of the two groups were higher than those before treatment,and the serum creatinine was lower than before treatment,and the serum creatinine of the observation group was lower than that of the control group,and the serum sodium and potassium levels were higher than those of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Before treatment,there were no significant differences in left ventricular ejection fraction (LVEF) and N-terminal pro brain natriuretic peptide (NT-proBNP) between the two groups (P＞0.05).After treatment,LVEF levels of the two groups were higher than before treatment,NT-proBNP were lower than before treatment,and NT-proBNP of the observation group was lower than that of the control group,LVEF level was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Tovastan combined with Berprost Sodium can effectively improve cardiac function,improve symptom relief time,no serious adverse reactions,and gradually return to normal biochemical indicators in patients with pulmonary hypertension heart failure.
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