标准外伤大骨瓣减压术联合高压氧治疗重型颅脑损伤患者的临床效果

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摘要目的探讨标准外伤大骨瓣减压术联合高压氧治疗重型颅脑损伤患者的临床效果。方法回顾性分析2018年2月至2019年2月辽宁省海城市中医院神经外科收治的120 例重型颅脑损伤患者的临床资料，根据治疗方法的不同将其分为对照组与观察组，每组各60 例。对照组患者采用标准外伤大骨瓣减压术治疗，观察组患者采用标准外伤大骨瓣减压术+高压氧治疗。比较两组患者的临床疗效、格拉斯哥预后评分量表（GCS）、美国国立卫生研究院卒中量表（NIHSS）评分和炎症因子水平[白介素-6（IL-6）、白介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）]。结果观察组患者的总有效率高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患者的GCS 高于治疗前，NIHSS 评分低于治疗前，差异有统计学意义（P＜0.05）；治疗后，观察组患者的GCS 高于对照组，NIHSS 评分低于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患者的IL-6、IL-8、TNF-α 水平低于治疗前，差异有统计学意义（P＜0.05）；治疗后，观察组患者的IL-6、IL-8、TNF-α 水平低于对照组，差异有统计学意义（P＜0.05）。结论经标准外伤大骨瓣减压术与高压氧联合治疗后，重型颅脑损伤患者的临床治疗效果较显著，炎症水平明显降低，且神经功能恢复及预后良好。

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关键词 ：重型颅脑损伤, 高压氧, 标准外伤大骨瓣减压术, 神经缺损, 预后, 炎症反应, 临床疗效, 联合治疗

Abstract：Objective To investigate the clinical effect of standard large traumatic bone flap decompression combined with hyperbaric oxygen in the treatment of severe craniocerebral injury. Methods The clinical data of 120 patients with severe craniocerebral injury admitted to the Department of Neurosurgery, Haicheng Hospital of Traditional Chinese Medicine, Liaoning Province from February 2018 to February 2019 were retrospectively analyzed. According to different treatment methods, they were divided into the control group and the observation group, with 60 cases in each group. Patients in control group were treated with standard large traumatic bone flap decompression, and patients in observation group were treated with standard large traumatic bone flap decompression plus hyperbaric oxygen therapy. Clinical efficacy, Glasgow coma scale (GCS), National Institutes of Health stroke scale (NIHSS) score and inflammatory factors(interleukin-6 [IL-6], interleukin-8 [IL-8], tumor necrosis factor-α [TNF-α]) were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, GCS of the two groups were higher than those before treatment,NIHSS scores were lower than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, GCS of observation group was higher than that of the control group, NIHSS score was lower than that of the control group, and the differences were statistically significant (P＜0.05). After treatment, the levels of IL-6, IL-8 and TNF-α in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,the levels of IL-6,IL-8 and TNF-α in observation group were lower than those in control group, and the differences were statistically significant (P＜0.05). Conclusion After standard decompression of large traumatic craniotomy combined with hyperbaric oxygen, the clinical treatment effect of severe craniocerebral injury patients is significant,the level of inflammation is significantly reduced, and the neurological function is recovered and the prognosis is good.

Key words： Severe craniocerebral injury')" href="#"> Severe craniocerebral injury Hyperbaric oxygen Standard trauma decompression of large bone flap;Nerve defect Prognosis Inflammatory response Clinical efficacy Combined therapy

引用本文:

隋斌. 标准外伤大骨瓣减压术联合高压氧治疗重型颅脑损伤患者的临床效果[J]. 中国当代医药, 2022, 29(4): 111-114.
SUI Bin. Clinical effect of standard large traumatic flap decompression combined with hyperbaric oxygen in the treatment of severe craniocerebral injury. 中国当代医药, 2022, 29(4): 111-114.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I4/111

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