重组人促红素联合硼替佐米和地塞米松治疗老年多发性骨髓瘤疗效评价

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摘要目的探讨重组人促红素联合硼替佐米和地塞米松治疗老年多发性骨髓瘤临床效果，以期为老年多发性骨髓瘤患者找到一种安全、高效的治疗方案。方法选取2016年1月至2021年4月广西医科大学附属武鸣医院收治的80 例老年多发性骨髓瘤患者作为研究对象，按照随机数字表法分为研究组（40 例）与对照组（40 例）。对照组采用硼替佐米联合地塞米松治疗方法，研究组采用重组人促红素、硼替佐米联合地塞米松治疗方法。比较两组的治疗总有效率、实验室指标及不良反应发生情况。结果研究组的总有效率为85.0%，高于对照组的72.5%，差异有统计学意义（P＜0.05）。治疗后研究组的血红蛋白、白蛋白高于对照组，肌酐、血清β2 微球蛋白、血钙低于对照组，差异有统计学意义（P＜0.05）。两组不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论针对多发性骨髓瘤患者采用重组人促红素、硼替佐米联合地塞米松治疗方案可获得良好疗效，改善其血液指标，安全性良好，值得临床应用与推广。

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关键词 ：重组人促红素, 硼替佐米, 地塞米松, 多发性骨髓瘤

Abstract：Objective To investigate the clinical effect of Recombinant Human Erythropoietin combined with Bortezomib and Dexamethasone in the treatment of elderly patients with multiple myeloma，in order to find a safe and efficient treatment plan for elderly patients with multiple myeloma. Methods A total of 80 elderly patients with multiple myeloma admitted to Wuming Hospital Affiliated to Guangxi Medical University from January 2016 to April 2021 were selected as the research subjects，and were divided into study group (40 cases) and control group (40 cases) according to random number table method. The control group was treated with Bortezomib combined with Dexamethasone，and the study group was treated with Recombinant Human Erythropoietin and Bortezomib combined with Dexamethasone. The total effective rate，laboratory indicators and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the study group was 85.0%，higher than that of the control group (72.5%)，and the difference was statistically significant (P＜0.05). After treatment，hemoglobin and albumin in the study group were higher than those in the control group，while creatinine，β2 microglobulin and serum calcium were lower than those in the control group，the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Recombinant Human Erythropoietin，Bortezomib and Dexamethasone for multiple myeloma patients can achieve good curative effect，improve the blood index，and have good safety，which is worthy of clinical application and promotion.

Key words： Recombinant Human Erythropoietin Bortezomib Dexamethasone Multiple myeloma

收稿日期: 2021-07-15

基金资助:广西壮族自治区卫生健康委员会自筹经费科研课题（Z20200136）

引用本文:

黄昭萍；杨灿华；梁入方；吕丽娜；谢兴文；梁韶文；黄玉娜；陈柳. 重组人促红素联合硼替佐米和地塞米松治疗老年多发性骨髓瘤疗效评价[J]. 中国当代医药, 2022, 29(1): 39-42.
HUANG Zhaoping YANG Canhua▲ LIANG Rufang LYU Lina XIE Xingwen LIANG Shaowen HUANG Yuna CHEN Liuxian. Evaluation of the efficacy of Recombinant Human Erythropoietin combined with Bortezomib and Dexamethasone in the treatment of multiple myeloma. 中国当代医药, 2022, 29(1): 39-42.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2022/V29/I1/39

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