综合护理干预对不同性别的抑郁症患者脑源性神经营养因子和皮质醇的表达影响

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摘要目的探讨综合护理干预对不同性别的抑郁症患者脑源性神经营养因子（BDNF）和皮质醇（Cor）表达影响。方法选取2018年8月～2019年8月我院收治的60例抑郁症患者为研究对象，按照随机数字表法分为对照组和研究组，每组各30例。对照组实施常规护理干预，研究组实施综合护理干预，为期8周。比较两组不同性别干预前BDNF和Cor的表达水平。结果两组干预前BDNF、Cor表达水平比较，差异无统计学意义（P＞0.05）；研究组男、女BDNF表达水平为（29.86±4.02）、（27.78±3.35）pg/ml，高于对照组的（26.14±3.71）、（24.36±3.29）pg/ml，两组干预后男、女患者BDNF表达水平高于干预前，差异均有统计学意义（P＜0.05）；研究组男、女Cor表达水平为（84.03±13.81）、（86.64±14.07）pg/ml，低于对照组的（97.56±14.52）、（100.12±15.92）pg/ml，两组干预后男、女患者Cor表达水平低于干预前，差异均有统计学意义（P＜0.05）。结论不同性别抑郁症患者实施综合护理干预效果显著，能改善患者BDNF和Cor的表达水平。

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	邱雪兰
	林彩凤
	汪珍艳
	殷凤莲

关键词 ：抑郁症, 性别, 综合护理干预, 脑源性神经营养因子, 皮质醇

Abstract：Objective To investigate the effects of comprehensive nursing intervention on the expression of brain-derived neurotrophic factor (BDNF) and cortisol (Cor) in patients with depression of differen genders.Methods A total of 60 patients with depression who were admitted to our hospital from August 2018 to August 2019 were selected as resear ch subjects.They were divided into control group and study group according to the random number table method,30 cases in each group.The control group u nderwent routine nursing intervention, and the study group implemented comprehensive nursing intervention for a period of 8 weeks.The expression levels of B DNF and Cor were compared between the two groups of patients with different genders before and after intervention.Results The expression of BDNF and Cor in the study group was not significantly different from those in the control group before intervention (P＞0.05).The expression level of BDNF i n male and female in the study group were (29.86±4.02) and (27.78±3.35) pg/ml, higher than those of the control group of (26.14±3.71) and (24.36±3.29) pg/ml, after interven tion, the expression levels of BDNF in male and female patients were higher than those before intervention, with significant differences (P＜0.05).The Cor expression levels of the study group in males and females were (84.03±13.81) and (86.64±14.07) pg/ml, which were lower than those of the control group of (97.56±14.52) and (100.12±15.92) pg/ml, the expression levels of Cor in male and female patients after intervention were lower than those before intervention, with significant differences (P＜0.05).Conclusion The effect of comprehensive nursing in tervention was significant in patients with depression of different genders, which could improve the expression level of BDNF and Cor.

Key words： Depression Gender Comprehensive nursing intervention Brain-derived neurotrophic factor Cortisol

基金资助:江西省上饶市科技计划项目（2019CKJ02）

作者简介: 邱雪兰（1977-），女，本科，主管护师，研究方向：精神病护理

引用本文:

邱雪兰；林彩凤；汪珍艳；殷凤莲. 综合护理干预对不同性别的抑郁症患者脑源性神经营养因子和皮质醇的表达影响[J]. 中国当代医药, 2020, 27(23): 202-204转208.
QIU Xue-lan；LIN Cai-feng；WANG Zhen-yan；YIN Feng-lian. Effect of comprehensive nursing intervention on the expression of BDNF and Cor in patients with depression of different genders. 中国当代医药, 2020, 27(23): 202-204转208.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I23/202

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