Meta-analysis of the effect of intravenous injection of iron disaccharide in the treatment of postpartum iron deficiency anemia
QIU Wen-wen1,2 WEI Li-li3,4 LI Hai-hong1,2▲ QIU Jie5 LIAN Rui-han1 HU Ya-guang5 LIU Yu-yu1,2 YANG Ke-hu
1.School of Nursing,Gansu University of Chinese medicine,Gansu Province,Lanzhou 730000,China;
2.Department of Nursing,Gansu Provincial Maternity and Child-care Hospital,Lanzhou 730050,China;
3.Center for Evidencebased Medicine,Lanzhou University,Gansu Province,Lanzhou 730030,China;
4.Key Laboratory of Evidence-based Medicine and Clinical Translational Medicine in Gansu Province,Lanzhou 730030,China;
5.Department of Administration,Gansu Provincial Maternity and Child-care Hospital,Lanzhou 730050,China
Abstract：Objective To systematically evaluate the effectiveness and safety of intravenous injection of iron disaccharide and oral ferrous sulfate in patients with postpartum iron deficiency anemia. Methods PubMed,Cochrane Library,Web of Science,EMbase,CBM,WanFang Data,CNKI,VIP database were searched by the computer.At the same time,the relevant references were traced,and the randomized controlled trials (RCTs) of the effect of the intravenous injection of iron disaccharide (iron sucrose,iron carboxymaltose) in the experimental group and the oral ferrous sulfate in the control group on hemoglobin and ferritin after postpartum iron deficiency anemia were collected.The retrieval period was from database construction to June 2019.According to the inclusion criteria and exclusion criteria,two researchers independently screened the literature,extracted the data and evaluated the risk of bias in the included study.Then,RevMan 5.3 software was used for Meta-analysis. Results A total of 1877 patients were included in 10 RCTs.Meta-analysis results showed that the hemoglobin levels of the experimental group were higher than those of the control group on 14 and 28 days after treatment,and the differences were statistically significant (SMD=0.39,95%CI[0.18,0.60],P=0.0003;SMD=0.78,95%CI [0.59,0.96],P<0.000 01).There were no statistically significant differences in ferritin and 24 h hemoglobin levels between the two groups after treatment (SMD=0.47,95%CI[-0.56,1.50],P=0.37;SMD=0.31,95%CI[-0.32,0.94],P=0.33).Conclusion Intravenous injection of iron disaccharide can improve the hemoglobin levels at 14 and 28 days and improve the clinical effectiveness.However,due to the limitations of the quantity and quality of the included studies,the above conclusions need to be verified by more high-quality randomized controlled studies.
邱文文；魏莉莉； 李海鸿；仇杰；练芮含； 虎亚光； 柳雨雨；杨克虎. 静脉注射二糖铁对产后缺铁性贫血治疗效果的Meta分析[J]. 中国当代医药, 2020, 27(21): 16-21.
QIU Wen-wen；WEI Li-li；LI Hai-hong； QIU Jie； LIAN Rui-han； HU Ya-guang；LIU Yu-yu；YANG Ke-hu. Meta-analysis of the effect of intravenous injection of iron disaccharide in the treatment of postpartum iron deficiency anemia. 中国当代医药, 2020, 27(21): 16-21.
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