| [1] |
Wang E，Merrill AJ.Ceramide synthase[J].Methods Enzymol，2000，311：15-21.
|
| [5] |
Zeidan YH，Hannun YA.Translational aspects of sphingolipid metabolism[J].Trends Mol Med，2007，13 （8）：327-336.
|
| [2] |
Michel C，van Echten-Deckert G，Rother J，et al.Characterization of ceramide synthesis.A dihydroceramide desaturase introduces the 4，5-trans-double bond of sphingosine at the level of dihydroceramide[J].J Biol Chem，1997，272（36）：22432-22437.
|
| [3] |
Ternes P，Franke S，Zahringer U，et al.Identification and characterization of a sphingolipid delta 4-desaturase family[J].J Biol Chem，2002，277（28）：25512-25518.
|
| [4] |
Li Z，Fan Y，Liu J，et al.Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice[J].Arterioscler Thromb Vasc Biol，2012，32（7）：1577-1584.
|
| [6] |
Taniguchi M，Okazaki T.The role of sphingomyelin and sphingomyelin synthases in cell death，proliferation and migration-from cell and animal models to human disorders[J].Biochim Biophys Acta，2014，1841（5）：692-703.
|
| [7] |
Albi E，Lazzarini R，Viola M M.Phosphatidylcholine/sphingomyelin metabolism crosstalk inside the nucleus[J].Biochem J，2008，410（2）：381-389.
|
| [8] |
Mayo MW，Baldwin AS.The transcription factor NF-kappaB：control of oncogenesis and cancer therapy resistance[J].Biochim Biophys Acta，2000，1470（2）：M55-M62.
|
| [9] |
Andrieu-Abadie N，Gouaze V，Salvayre R，et al.Ceramide in apoptosis signaling：relationship with oxidative stress[J].Free Radic Biol Med，2001，31（6）：717-728.
|
| [10] |
Haimovitz-Friedman A，Kolesnick RN，Fuks Z.Ceramide signaling in apoptosis[J].Br Med Bull，1997，53（3）：539-553.
|
| [11] |
Ravid T，Tsaba A，Gee P，et al.Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells[J].Am J Physiol Lung Cell Mol Physiol，2003，284（6）：L1082-L1092.
|
| [12] |
Villani M，Subathra M，Im YB，et al.Sphingomyelin synthases regulate production of diacylglycerol at the Golgi[J].Biochem J，2008，414（1）：31-41.
|
| [13] |
Altura BM，Shah NC，Li Z，et al.Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells：relevance to the de novo synthesis of ceramide[J].Am JPhysiol Heart Circ Physiol，2010，299（6）：H2046-H2055.
|
| [14] |
Simons K，Ikonen E.How cells handle cholesterol[J].Science，2000，290（5497）：1721-1726.
|
| [15] |
Prinetti A，Chigorno V，Prioni S，et al.Changes in the lipid turnover，composition，and organization，as sphingolipidenriched membrane domains，in rat cerebellar granule cells developing in vitro[J].JBiol Chem，2001，276（24）：21136-21145.
|
| [16] |
Fruhwirth GO，Hermetter A.Mediation of apoptosis by oxidized phospholipids[J].Subcell Biochem，2008，49：351-367.
|
| [17] |
Peetla C，Bhave R，Vijayaraghavalu S，et al.Drug resistance in breast cancer cells：biophysical characterization of and doxorubicin interactionswith membranelipids[J].Mol Pharm，2010，7（6）：2334-2348.
|
| [18] |
Hendrich AB，Michalak K.Lipids as a target for drugs modulating multidrug resistance of cancer cells[J].Curr Drug Targets，2003，4（1）：23-30.
|
| [21] |
Klumperman J.Architecture of the mammalian Golgi[J].Cold Spring Harb Perspect Biol，2011，3（7）：a005181.
|
| [25] |
Bismuth J，Lin P，Yao Q，et al.Ceramide：a common pathway for atherosclerosis?[J].Atherosclerosis，2008，196 （2）：497-504.
|
| [37] |
Adada M，Luberto C，Canals D.Inhibitorsof thesphingomyelin cycle：sphingomyelin synthases and sphingomyelinases[J].Chem Phys Lipids，2016，197：45-59.
|
| [19] |
Pallares-Trujillo J，Lopez-Soriano FJ，Argiles JM.Lipids：a key role in multidrug resistance （Review）[J].Int JOncol，2000，16（4）：783-798.
|
| [20] |
Emr S，Glick BS，Linstedt AD，et al.Journeys through the Golgi--taking stock in a new era[J].J Cell Biol，2009，187（4）：449-453.
|
| [22] |
Duran J M，Campelo F，van Galen J，et al.Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex[J].EMBOJ，2012，31（24）：4535-4546.
|
| [23] |
van Galen J，Campelo F，Martinez -Alonso E，et al.Sphingomyelin homeostasis is required to form functional enzymatic domains at the trans-Golgi network[J].J Cell Biol，2014，206（5）：609-618.
|
| [24] |
Tabas I.Sphingolipids and atherosclerosis：a mechanistic connection：A therapeutic opportunity?[J].Circulation，2004，110（22）：3400-3401.
|
| [26] |
Slotte JP，Bierman EL.Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasmamembranesand intracellular cholesterol pools in cultured fibroblasts[J].Biochem J，1988，250（3）：653-658.
|
| [27] |
Amaro M，Sachl R，Aydogan G，etal.GM1Ganglioside Inhibits beta-Amyloid Oligomerization Induced by Sphingomyelin[J].Angew Chem Int Ed Engl，2016，55（32）：9411-9415.
|
| [28] |
Kurek K，Piotrowska DM，Wiesiolek-Kurek P，et al.Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease[J].Liver Int，2014，34（7）：1074-1083.
|
| [29] |
Rao RP，Scheffer L，Srideshikan SM，et al.Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells[J].PLoSOne，2014，9（3）：e92142.
|
| [30] |
Separovic D，Shields AF，Philip PA，et al.Altered levels of serum ceramide，sphingosine and sphingomyelin are associated with colorectal cancer：a retrospective pilot study[J].Anticancer Res，2017，37（3）：1213-1218.
|
| [31] |
Gutner UA，Dudnik LB，Korobko VG，et al.The influence of tumor necrosis factor alpha on the processes of sphingomyelin cycle and lipid peroxidation in brain[J].Zh Nevrol Psikhiatr Im SSKorsakova，2005，105（4）：48-54.
|
| [32] |
Heinz LX，Baumann CL，Koberlin MS，et al.The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity[J].Cell Rep，2015，11（12）：1919-1928.
|
| [40] |
Bienias K，Fiedorowicz A，Sadowska A，et al.Regulation of sphingomyelin metabolism[J].Pharmacol Rep，2016，68（3）：570-581.
|
| [33] |
Martinez-Beamonte R，Lou-Bonafonte JM，Martinez-Gracia MV，et al.Sphingomyelin in high-density lipoproteins：structural role and biological function[J].Int JMol Sci，2013，14（4）：7716-7741.
|
| [34] |
Andrieu N，Salvayre R，Jaffrezou J P，et al.Low temperatures and hypertonicity do not block cytokine-induced stimulation of the sphingomyelin pathway but inhibit nuclear factor-kappa Bactivation[J].JBiol Chem，1995，270（41）：24518-24524.
|
| [35] |
Lou B，Dong J，Li Y，et al.Pharmacologic inhibition of sphingomyelin synthase（SMS）activity reduces apolipoprotein-B secretion from hepatocytes and attenuates endotoxinmediated macrophageinflammation[J].PLoSOne，2014，9（7）：e102641.
|
| [36] |
Kol M，Panatala R，Nordmann M，et al.Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases[J].JLipid Res，2017，58（5）：962-973.
|
| [38] |
Nelson JC，Jiang XC，Tabas I，et al.Plasma sphingomyelin and subclinical atherosclerosis：findings from the multiethnic study of atherosclerosis[J].Am JEpidemiol，2006，163（10）：903-912.
|
| [39] |
Subbaiah PV，Subramanian VS，Wang K.Novel physiological function of sphingomyelin in plasma.Inhibition of lipid peroxidation in low density lipoproteins[J].J Biol Chem，1999，274（51）：36409-36414.
|
| [41] |
Ilan Y.Compounds of the sphingomyelin-ceramide-glycosphingolipid pathwaysassecondary messenger molecules：new targets for novel therapies for fatty liver disease and insulin resistance[J].Am JPhysiol Gastrointest Liver Physiol，2016，310（11）：G1102-G1117.
|
京公网安备 11010502046607号