Effect observation of 75% alcohol+Haijinsha fresh grass pounding mud for external use combined with Acyclovir in the treatment of herpes zoster neuralgia
LI Shi-ping CHEN Ye-fei DENG Liang-yuan YAN Jian-yong HU Yao LI Wei
Department of Neurology,Lianhua County People′s Hospital,Jiangxi Province,Pingxiang 337100,China
Abstract： Objective To explore the effect of 75% alcohol+Haijinsha fresh grass pounding mud for external use combined with Acyclovir in the treatment of herpes zoster neuralgia.Methods The 30 patients with herpes zoster neuralgia who refused to be admitted to Lianhua County People′s Hospital from December 2016 to April 2020 were selected as the control group,and the 30 patients with herpes zoster neuralgia who received hospitalization during the same period were selected as the observation group.The control group received conventional treatment,namely oral and external acyclovir.On this basis,the observation group combined topical 75% alcohol+Haijinsha fresh grass pounding mud for treatment.The clinical efficacy,symptom relief time,pain degree (visual analogue scale [VAS]) before and after treatment and the changes of inflammatory factors were compared between the two groups of patients,which included interleukin 6(IL-6),serum high-sensitivity C-reactive protein (hs-CRP),necrosis factor-α(TNF-α).Results The total effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant (P＜0.05).The redness,swelling,scab,and neuralgia relief time of the observation group were all higher than those in the control group,the differences were statistically significant (P＜0.05).There was no statistically significant difference between the VAS scores of the two groups before treatment (P＞0.05);the VAS scores of the two groups after treatment were lower than before treatment,and the VAS score of the observation group was lower than in the control group,the difference was statistically significant (P＜0.05).The hs-CRP,IL-6 and TNF-α before treatment in the two groups were not statistically significant (P＞0.05);the hs-CRP,IL-6 and TNF-α after treatment in both groups were lower than before treatment,and the levels in the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).Conclusion For the treatment of herpes zoster neuralgia,using 75%alcohol+Haijinsha fresh grass pounding mud external application combined with Acyclovir treatment has a significant effect,which can effectively shorten the course of the disease,relieve pain,inhibit the release of serum inflammatory factors,and promote the reduction or disappearance of symptoms.It is worth studying in the future.
李石平 陈烨菲 邓良元 颜建勇 胡 尧 李 伟. 75%酒精+海金沙鲜草捣草泥外用联合阿昔洛韦治疗带状疱疹神经痛效果观察[J]. 中国当代医药, 2020, 27(32): 40-42.
LI Shi-ping CHEN Ye-fei DENG Liang-yuan YAN Jian-yong HU Yao LI Wei. Effect observation of 75% alcohol+Haijinsha fresh grass pounding mud for external use combined with Acyclovir in the treatment of herpes zoster neuralgia
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